PacBio to commence first customer shipments of Revio long-read sequencing systems

PacBio, a leading developer of high-quality, highly accurate sequencing solutions, today announced its first customer shipments of Revio long-read sequencing systems will commence on March 8, 2023. As previously announced, the Revio system features significant advances in SMRT Cell design, compute, and system architecture. Together, this enables a dramatic increase in throughput and lower sequencing costs with the trusted power of HiFi chemistry, which offers exceptional accuracy and direct methylation detection.

Revio is a remarkable product, and I am excited to announce the commencement of broad commercial shipments. This is an important step in our mission to enable the promise of genomics to better human health and, it is rewarding to see our team successfully execute on our aggressive product development timeline. The Revio system will empower our customers to leverage the power of HiFi sequencing at scale and I believe the system will enable a significant paradigm shift in our understanding of biology.”

Christian Henry, President and Chief Executive Officer, PacBio.

With the Revio system, researchers will be able to scale their interrogation of the full genome: from telomere-to-telomere with phasing information, small variants, structural variants, and epigenetic profiles all in the same run. This will allow further exploration of biology and offers the potential to better understand the role of genetics in health and disease.

Among the first customers receiving Revio systems are many of the original Human Genome Project sequencing centers: Baylor College of Medicine, the Broad Institute of MIT and Harvard (Broad), Wellcome Sanger Institute, and Washington University in St. Louis. Broad is one of many customers to purchase multiple systems, ordering ten Revio systems to scale long-read sequencing for population sequencing initiatives. The ten Revio systems at Broad will have the same sequencing capacity as 150 Sequel IIe systems.

With the increased capacity now available, the Broad is looking to scale up significantly and complete several thousand long-read sequencing samples. We are focused on proving the utility of long-read sequencing in research and rare disease applications. We are also excited to continue to investigate and push the boundaries of how long-read sequencing could transform discovery with higher resolution isoform sequencing.”

Niall Lennon, Senior Director of Translational Genomics and Institute Scientist, Broad Institute of MIT and Harvard.

In the plant and animal genomic space, the HudsonAlpha Institute for Biotechnology in Huntsville, Ala., plans to use its Revio systems to scale its efforts to improve crop species. “We can make a big impact when we scale genomics for breeding,” said Josh Clevenger, Ph.D., Faculty Investigator at HudsonAlpha. “It has been difficult to generate enough good quality genomes to understand variation. With the Revio system’s high throughput and high-quality reads, we will be able to quickly and cost-effectively look at genomes to identify traits.”

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