Visceral Obesity Linked to Higher Incidence of CRC

The study covered in this summary was published on ResearchSquare.com as a preprint and has not yet been peer reviewed.

Key Takeaway

• This study reported that patients with visceral adiposity, including patients with diabetes and metabolic syndrome, were found to have high incidence of colorectal cancer and colorectal adenoma compared with a control group of patients without neoplastic disease.

Why This Matters

• The study provides insight on potential physical exam and laboratory predictors of colorectal cancer.

• These metabolism-related routine laboratory tests and anthropometric measurements may be used to screen high-risk patients for colorectal cancer to promote early detection and treatment.

Study Design

• This retrospective, case-control study selected a cohort of 80 patients with colorectal cancer, 80 patients with colorectal adenoma, and 80 patients with non-neoplastic disease from one nursing unit between April 2017 and April 2019. Patients with non-neoplastic disease were matched to patients with colorectal cancer on the basis of sex and age.

• Exclusion criteria included a history of cancer, incomplete colonoscopy, inflammatory bowel disease, history of familial adenomatous polyposis syndrome, evident edema, seroperitoneum, and incomplete data.

• Waist, hip, and neck circumferences were measured using bony anatomy structures.

• Laboratory measures of hemoglobin, albumin, and plasma glucose and lipid profile were collected by standard methods after overnight fasting.

Key Results

• The study reported a higher prevalence of diabetes (P = .016) among patients with colorectal cancer compared with patients without neoplastic disease.

• Patients with diabetes, metabolic syndrome, and high waist-to-neck ratio were found to have a high incidence of colorectal cancer and colorectal adenoma.

• Metabolic syndrome, high waist-to-neck ratio (odds ratio [OR], 2.795), and high waist-to-height ratio (OR, 3.009) were associated with an increased risk for colorectal cancer in male patients.

• In female patients, only high waist-to-hip ratio was found to be a high-risk factor (multivariable adjusted OR, 3.354).

• Anemia, hypoproteinemia, and self-reported weight loss were associated with a higher incidence of colorectal cancer compared with colorectal adenoma.

Limitations

• Selection bias may be present owing to the retrospective design of the study.

• The study was a single-center study with a small number of patients with colorectal cancer; thus, results will need to be further evaluated in multiple-center research.

• Only hospitalized individuals were included in this study, and so results cannot be generalized to a social normal population.

Disclosures

• The study was supported by the Exceptional Young Talents Fostering Foundation 2021 of the Tianjin Fourth Central Hospital (tjdszxyy20210013).

• The authors declared no competing interests.

This is a summary of a preprint research study, “Prediction of the Incidence of Colorectal Cancer by Routine Laboratory Tests and Anthropometric Measurements About Metabolism,” published August 9 on ResearchSquare.com and led by Binglu Chen of the Fourth Central Hospital, affiliated with Nankai University in Tianjin, China. This study has not yet been peer reviewed. The full text of the study can be found on ResearchSquare.com.

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